The aim of the study was to find the most balanced plan with an optimal combination of planning parameters in helical tomotherapy (HT) for bilateral breast irradiation by evaluating dosimetric indices and time factors. In particular, we investigated the best combination of field width (FW), pitch, and modulation factor (MF).
A total of 90 plans (18 plans for each patient) was created in this study, with different combination of planning parameters (FW 2.5 cm [F1] and 5 cm [F2]; pitch 0.215 [P1], 0.287 [P2], and 0.43 [P3]; and MF 2.0 [M1], 2.5 [M2], and 3.0 [M3]). Plans were analyzed using several dosimetric indices homogeneity index, conformity index, dose near minimum D, dose near maximum D, and the coverage by Dof the target. Organ at risk (OAR) doses were evaluated by mean dose, Vand Vfor the heart and mean dose Vand Vfor both the lungs. Treatment time was also reported for all plans.
Reducing FW from 5 cm to 2.5 cm increased the treatment time by 40%-50% and improved homogeneity of the target. Tightening the pitch value from 0.43 to 0.215 improved target as well as OAR doses without increasing the treatment time. Increasing MF from 2 to 3 improved all the dosimetric indices and also increased treatment time.
On the basis of our analysis, a plan with FW 5 cm, pitch 0.215, and MF 2.5 can be considered as an optimal combination of planning parameters for bilateral breast irradiation in HT technique.
On the basis of our analysis, a plan with FW 5 cm, pitch 0.215, and MF 2.5 can be considered as an optimal combination of planning parameters for bilateral breast irradiation in HT technique.The aim of this study is to validate the clinical use of flattening filter-free (FFF) beam-based volumetric-modulated arc therapy (VMAT) in synchronous bilateral breast carcinoma (SBBC) patient treatments and to compare with flattening filtered (FF) beam-based VMAT.
Computed tomography images of 15 SBBC patients were taken for this study. A dose of 50 Gy in 25 fractions was prescribed to planning target volume (PTV). VMAT plans were generated using both FFF and FF 6 MV X-ray beams in Eclipse treatment planning system. PTV and organs at risk (OARs) doses were analyzed quantitatively using dose-volume histograms (DVHs) to meet plan objectives. Pretreatment point and planar dosimetry were performed.
The findings were reported as mean ± 1 standard deviation. PTV volume receiving 95% of the prescribed dose was 95.71% ± 0.65% for FF-VMAT and 95.45% ± 1.33% for FFF-VMAT (= 0.743). Conformity index was 1.12 ± 0.31 (FF-VMAT) and 1.12 ± 0.02 (FFF-VMAT). Right lung mean dose was 10.95 ± 1.33 Gy (FF-VMAT) and 10.60 ± 98.5 (FFF-VMAT). Left lung mean dose was 9.73 ± 1.56 (FF-VMAT) and 9.61 ± 1.53 Gy (FFF-VMAT). Tumor control probability (TCP) was 99.68% ± 0.02% (FF-VMAT) and 99.67% ± 0.01% (FFF-VMAT) (= 0.390). Uncomplicated TCP was 98.72% ± 0.02% (FF-VMAT) and 98.72% ± 0.01% (FFF-VMAT) (= 0.508).
The planning objective parameters achieved using FFF-based VMAT showed that FFF can also be used clinically to treat bilateral breast carcinomas and the low-dose lung volumes were still lesser with FFF-VMAT plans than FF-VMAT.
The planning objective parameters achieved using FFF-based VMAT showed that FFF can also be used clinically to treat bilateral breast carcinomas and the low-dose lung volumes were still lesser with FFF-VMAT plans than FF-VMAT.Source modeling is an approach to reduce computational burden in Monte Carlo simulations but at the cost of reduced accuracy. Although this method can be effective, one component of the source model that is exceptionally difficult to model is the electron contamination, a significant contributor to the skin and shallow dose.
To improve the accuracy for the electron contamination component of the overall source model, we have generated a spatial mesh based surface source model.
The source model is located downstream from the flattening filter and mirror but upstream from the movable jaws. A typical phase space file uses around ten parameters per particle, but this method simplifies this number to five components. By using only the electron distance from the central axis, angles from the central axis and energy, the computational time and disk space required is greatly reduced.
Despite the simplification in the source model, the electron contamination is still accurate to within 1.5%.
Despite the simplification in the source model, the electron contamination is still accurate to within 1.5%.The objective of this study was to evaluate skin dose based on retrofit prototype multileaf collimators (MLCs), designed for cobalt-60 teletherapy machine. Since patient's skin is sensitive to radiation, evaluation of skin dose is of utmost importance for investigating the risk of late effects.
Measurements were performed with a Phoenix cobalt-60 teletherapy machine and the detector used was EBT3 radiochromic film. The experiments were performed in a solid water phantom with two prototype MLCs mounted to the machine. Dose readings were taken by placing the films at source-to-surface distance (SSD) of 60 cm, 65 cm, 70 cm, 75 cm, 80 cm, 85 cm, and 90 cm for various MLC-generated field sizes starting from 2 cm × 2 cm to 14 cm × 14 cm. The films were analyzed using custom made programs. The measured doses were normalized to the dose at dmax for that particular measurement of SSD.
The skin dose is expressed as a percentage of dose at dose maximum. In general, the skin dose increases with field size and decreases with SSD. The measurements indicate surface doses within 20%-60% for the investigated SSD range. Furthermore, there is no significant difference between the surface doses of two prototype MLCs studied.
From the measurements, it can be concluded that there is good skin sparing even at close distance to the MLCs. The skin dose is &lt;50% for SSDs &gt;65 cm. A minimum gap of 5 cm is required to produce acceptable skin dose.
65 cm. A minimum gap of 5 cm is required to produce acceptable skin dose.To analyze robustness of treatment plans optimized using different approaches in intensity modulated proton therapy (IMPT) and investigate the necessity of robust optimization and evaluation in intensity modulated radiotherapy (IMRT) plans for skull base chordomas.
Two photon plans, standard IMRT and robustly optimized IMRT (RB-IMRT), and two IMPT plans, robustly optimized multi field optimization (MFO) and hybrid-MFO (HB-MFO), were created in RayStation TPS for five patients previously treated using single field uniform optimization (SFO). https://www.selleckchem.com/products/trc051384.html Both set-up and range uncertainties were incorporated during robust optimization of IMPT plans whereas only set-up uncertainty was used in RB-IMRT. The dosimetric outcomes from the five planning techniques were compared for every patient using standard dose volume indices and integral dose (ID) estimated for target and organs at risk (OARs). Robustness of each treatment plan was assessed by introducing set-up uncertainties of ±3 mm along the three translational axes and, only in protons, an additional range uncertainty of ±3.